Republican legislators with more Latinos in their districts are more likely to vote to restrict immigration

In recent years, immigration has emerged as one of the most important issues that Americans believe the country faces. But what affects how legislators vote on immigration issues? In new research on state-based immigration legislation, James Avery and Jeff Fine find that when an area has more Latinos, Republicans who represent them are more likely to vote for restrictive immigration policies, while Democrats are consistent in their opposition to such measures no matter the number of Latinos in their district

Enhanced Multi-Touch Gestures for Complex Tasks

Recent technological advances have resulted in a major shift, from high-performance notebook and desktop computers -- devices that rely on keyboard and mouse for input -- towards smaller, personal devices like smartphones, tablets and smartwatches which rely primarily on touch input. Users of these devices typically have a relatively high level of skill in using multi-touch gestures to interact with them, but the multi-touch gesture sets that are supported are often restricted to a small subset of one and two-finger gestures, such as tap, double tap, drag, flick, pinch and spread. This is not due to technical limitations, since modern multi-touch smartphones and tablets are capable of accepting at least ten simultaneous points of contact. Likewise, human movement models suggest that humans are capable of richer and more expressive forms of interaction that utilize multiple fingers. This suggests a gap between the technical capabilities of multi-touch devices, the physical capabilities of end-users, and the gesture sets that have been implemented for these devices. Our work explores ways in which we can enrich multi-touch interaction on these devices by expanding these common gesture sets. Simple gestures are fine for simple use cases, but if we want to support a wide range of sophisticated behaviours -- the types of interactions required by expert users -- we need equally sophisticated capabilities from our devices. In this thesis, we refer to these more sophisticated, complex interactions as `enhanced gestures' to distinguish them from common but simple gestures, and to suggest the types of expert scenarios that we are targeting in their design. We do not need to necessarily replace current, familiar gestures, but it makes sense to consider augmenting them as multi-touch becomes more prevalent, and is applied to more sophisticated problems. This research explores issues of approachability and user acceptance around gesture sets. Using pinch-to-zoom as an example, we establish design guidelines for enhanced gestures, and systematically design, implement and evaluate two different types of expert gestures, illustrative of the type of functionality that we might build into future systems

Détection de la manualité via les capteurs d'orientation du smartphone lors de la prise en main

National audiencePeople often switch hands while holding their phones, based on task and context. Ideally, we would be able to detect which hand they are using to hold the device, and use this information to optimize the interaction. We introduce a method to use built-in orientation sensors to detect which hand is holding a smartphone prior to first interaction. Based on logs of people picking up and unlocking a smartphone in a controlled study, we show that a dynamic-time warping approach trained with user-specific examples achieves 83.6% accuracy for determining which hand is holding the phone, prior to touching the screen.En fonction de la tâche et du contexte, les utilisateurs de smartphone ont pour habitude de changer de main pour tenir leur appareil. Idéalement, nous souhaiterions connaître la main utilisée afin d'optimiser l'interaction. A cet effet, nous introduisons une méthode utilisant les capteurs d'orientation intégrés afin de déterminer la main tenant le smartphone avant toute interaction. Nous montrons, par l'analyse des données de participants prenant et déverrouillant leurs smartphones durant une expérience contrôlée, qu'une approche utilisant l'algorithme Dynamic-Time Warping permet d'obtenir une précision de 83.6% afin de détecter la main utilisée

Quantitative trait locus-specific genotype × alcoholism interaction on linkage for evoked electroencephalogram oscillations

We explored the evidence for a quantitative trait locus (QTL)-specific genotype × alcoholism interaction for an evoked electroencephalogram theta band oscillation (ERP) phenotype on a region of chromosome 7 in participants of the US Collaborative Study on the Genetics of Alcoholism. Among 901 participants with both genotype and phenotype data available, we performed variance component linkage analysis (SOLAR version 2.1.2) in the full sample and stratified by DSM-III-R and Feighner-definite alcoholism categories. The heritability of the ERP phenotype after adjusting for age and sex effects in the combined sample and in the alcoholism classification sub-groups ranged from 40% to 66%. Linkage on chromosome 7 was identified at 158 cM (LOD = 3.8) in the full sample and at 108 in the non-alcoholic subgroup (LOD = 3.1). Further, we detected QTL-specific genotype × alcoholism interaction at these loci. This work demonstrates the importance of considering the complexity of common complex traits in our search for genes that predispose to alcoholism

Accuracy of haplotype estimation in a region of low linkage disequilibrium

Abstract We compared the accuracy of haplotype inferences at a 6 Mb region on chromosome 7 where significant linkage between a brain oscillation phenotype and a cholinergic muscarinic receptor gene was previously reported. Individual haplotype assignments and haplotype frequencies were estimated using 5, 10, and 14 consecutive Illumina single-nucleotide polymorphisms (SNPs) within the 1-LOD unit support interval of the chromosome 7 linkage peak. Initially, haplotypes were constructed incorporating phase information provided by relatives using the pedigree analysis package MERLIN. Population-based haplotypes were inferred using the haplotype estimation software HAPLO.STATS and PHASE, using unrelated individuals. The 14 SNPs within this region exhibited markedly low linkage disequilibrium, and the average D' estimate between SNPs was 0.18 (range: 0.01–0.97). In comparison to the family-based haplotypes calculated in MERLIN, the computational inferences of individual haplotype assignments were most accurate when considering 5 consecutive SNPs, but decayed dramatically when considering 10 or 14 SNPs in both PHASE and HAPLO.STATS. When comparing the two haplotype inference methods, both PHASE and HAPLO.STATS performed poorly. These analyses underscore the difficulties of haplotype estimation in the presence of low linkage disequilibrium and stress the importance of careful consideration of confidence measures when using estimated haplotype frequencies and individual assignments in biomedical research

Quantitative trait locus-specific genotype x alcoholism interaction on linkage for evoked electroencephalogram oscillations

Abstract We explored the evidence for a quantitative trait locus (QTL)-specific genotype × alcoholism interaction for an evoked electroencephalogram theta band oscillation (ERP) phenotype on a region of chromosome 7 in participants of the US Collaborative Study on the Genetics of Alcoholism. Among 901 participants with both genotype and phenotype data available, we performed variance component linkage analysis (SOLAR version 2.1.2) in the full sample and stratified by DSM-III-R and Feighner-definite alcoholism categories. The heritability of the ERP phenotype after adjusting for age and sex effects in the combined sample and in the alcoholism classification sub-groups ranged from 40% to 66%. Linkage on chromosome 7 was identified at 158 cM (LOD = 3.8) in the full sample and at 108 in the non-alcoholic subgroup (LOD = 3.1). Further, we detected QTL-specific genotype × alcoholism interaction at these loci. This work demonstrates the importance of considering the complexity of common complex traits in our search for genes that predispose to alcoholism

Microcystin Prevalence throughout Lentic Waterbodies in Coastal Southern California.

Toxin producing cyanobacterial blooms have increased globally in recent decades in both frequency and intensity. Despite the recognition of this growing risk, the extent and magnitude of cyanobacterial blooms and cyanotoxin prevalence is poorly characterized in the heavily populated region of southern California. Recent assessments of lentic waterbodies (depressional wetlands, lakes, reservoirs and coastal lagoons) determined the prevalence of microcystins and, in some cases, additional cyanotoxins. Microcystins were present in all waterbody types surveyed although toxin concentrations were generally low across most habitats, as only a small number of sites exceeded California's recreational health thresholds for acute toxicity. Results from passive samplers (Solid Phase Adsorption Toxin Tracking (SPATT)) indicated microcystins were prevalent throughout lentic waterbodies and that traditional discrete samples underestimated the presence of microcystins. Multiple cyanotoxins were detected simultaneously in some systems, indicating multiple stressors, the risk of which is uncertain since health thresholds are based on exposures to single toxins. Anatoxin-a was detected for the first time from lakes in southern California. The persistence of detectable microcystins across years and seasons indicates a low-level, chronic risk through both direct and indirect exposure. The influence of toxic cyanobacterial blooms is a more complex stressor than presently recognized and should be included in water quality monitoring programs

Accuracy of haplotype estimation in a region of low linkage disequilibrium

We compared the accuracy of haplotype inferences at a 6 Mb region on chromosome 7 where significant linkage between a brain oscillation phenotype and a cholinergic muscarinic receptor gene was previously reported. Individual haplotype assignments and haplotype frequencies were estimated using 5, 10, and 14 consecutive Illumina single-nucleotide polymorphisms (SNPs) within the 1-LOD unit support interval of the chromosome 7 linkage peak. Initially, haplotypes were constructed incorporating phase information provided by relatives using the pedigree analysis package MERLIN. Population-based haplotypes were inferred using the haplotype estimation software HAPLO.STATS and PHASE, using unrelated individuals. The 14 SNPs within this region exhibited markedly low linkage disequilibrium, and the average D' estimate between SNPs was 0.18 (range: 0.01–0.97). In comparison to the family-based haplotypes calculated in MERLIN, the computational inferences of individual haplotype assignments were most accurate when considering 5 consecutive SNPs, but decayed dramatically when considering 10 or 14 SNPs in both PHASE and HAPLO.STATS. When comparing the two haplotype inference methods, both PHASE and HAPLO.STATS performed poorly. These analyses underscore the difficulties of haplotype estimation in the presence of low linkage disequilibrium and stress the importance of careful consideration of confidence measures when using estimated haplotype frequencies and individual assignments in biomedical research

Microcystin Prevalence throughout Lentic Waterbodies in Coastal Southern California.

Toxin producing cyanobacterial blooms have increased globally in recent decades in both frequency and intensity. Despite the recognition of this growing risk, the extent and magnitude of cyanobacterial blooms and cyanotoxin prevalence is poorly characterized in the heavily populated region of southern California. Recent assessments of lentic waterbodies (depressional wetlands, lakes, reservoirs and coastal lagoons) determined the prevalence of microcystins and, in some cases, additional cyanotoxins. Microcystins were present in all waterbody types surveyed although toxin concentrations were generally low across most habitats, as only a small number of sites exceeded California's recreational health thresholds for acute toxicity. Results from passive samplers (Solid Phase Adsorption Toxin Tracking (SPATT)) indicated microcystins were prevalent throughout lentic waterbodies and that traditional discrete samples underestimated the presence of microcystins. Multiple cyanotoxins were detected simultaneously in some systems, indicating multiple stressors, the risk of which is uncertain since health thresholds are based on exposures to single toxins. Anatoxin-a was detected for the first time from lakes in southern California. The persistence of detectable microcystins across years and seasons indicates a low-level, chronic risk through both direct and indirect exposure. The influence of toxic cyanobacterial blooms is a more complex stressor than presently recognized and should be included in water quality monitoring programs